Joel Kowalewski
Computational Neuroscience & Biology
Accelerating Discoveries Through AI
MoreUncovering the physicochemical basis of odor perception and developing machine learning/AI platforms to discover chemicals with specific perceptual qualities. The work has been applied to identify topical insect repellents with more appealing properties.
Searching for pyrethroid and DEET substitutes from millions of chemical possibilities.
Application of machine learning/AI to identify candidate drugs as repurposed Covid-19 treatments or to discover new compounds that target virus entry and replication.
Drosophila odor valence can be modeled by physicochemical features and in vivo recorded neural activity. Few of the many odorant receptor activities in the fly are highly predictive of the observed behavior.
Developing statistical models from brain imaging data to diagnose individuals genetically at risk for Alzheimer's disease.